Rónán Daly, Kieron D. Edwards, John S. O’Neill, Stuart Aitken, Andrew J. Millar and Mark Girolami.
In Proceedings of the Fourth IAPR International Conference on Pattern Recognition in Bioinformatics (PRIB 2009), volume 5780 of Lecture Notes in Bioinformatics, pages 67–78, 2011
Modelling gene regulatory networks in organisms is an important task that has recently become possible due to large scale assays using technologies such as microarrays. In this paper, the circadian clock of Arabidopsis thaliana is modelled by fitting dynamic Bayesian networks to luminescence data gathered from experiments. This work differs from previous modelling attempts by using higher-order dynamic Bayesian networks to explicitly model the time lag between the various genes being expressed. In order to achieve this goal, new techniques in preprocessing the data and in evaluating a learned model are proposed. It is shown that it is possible, to some extent, to model these time delays using a higher-order dynamic Bayesian network.